Casting hydrophilic polymers blended polycaprolactone membranes for drug delivery to eradicate the cancer cells and pathogenic microorganisms

Abstract Hydrophilic polymers have been recognized for enhancing the physico‐chemical and biological properties of synthetic polyesters in field cancer treatment tissue engineering. In this article, anticancer drug, 5‐fluorouracil loaded membranes were prepared with polycaprolactone blended chitosan, hydroxypropyl methyl cellulose polyethylene glycol to study drug release ability breast alongside microbial infections. Solution casting method was employed fabricate blend a combination synthetic, natural hydrophilic resulted characterized by spectral, crystallographic, surface morphology, contact angle measurements mechanical testing. Through spectral crystallographic study, crosslinking chemical interactions between confirmed. Swelling capacity, loading efficiency profile studied an optimal from observed. The showed cell viability 60%–85% against fibroblast line cytotoxicity 60%–76% cells. Furthermore, growth inhibition assay results revealed that possess good inhibiting property selected bacterial fungal strains. vitro degradation studies reveals rate found higher compared bare membrane. Hence, obtained clearly fabricated would be promising biomaterial implant cells post‐surgical